REVIEWS

 

Programmable DNA binding oligomers for control of transpcription in angiogenesis

Sarah Furkan

 

EMAN Research and Testing Laboratory, Department of Pharmacology, School of Pharmaceutical Sciences, Universiti Sains Malaysia, Penang, Malaysia

*Corresponding Author. E-mail: sara.creed89@yahoo.com

 

Angiotherapy, 2017, 1(1), 033–035. (Received 11 September 2016, Published 10 May 2017). 

https://doi.org/10.25163/angiotherapy.11000721108100517

 

Citation: Sarah Furqan. (2017). Programmable DNA Binding Oligomers for Control of Transcription in angiogenesis. Angiotherapy, 1(1), pages 033-035.

Abstract

The drug discovery opportunities with chemistry, biology and human medicine are increasing by mapping and sequencing the genetic blueprint of humans, mice and other organisms. The realization of the function of 25,000 genes of humans and understanding the biological circles that control these genes will be a crucial starting point for new chemistry technologies. The cellular events that lead to cancer and diseases in human involve aberrant gene expression. Small molecules that can be programmed to mimic transcription factors could be useful tools in biology and potentially in human medicine as they could bind a large repertoire of DNA sequences in the human genome.

 

Keywords: Transcription, Oligomers, DNA, Chromatin, Drug Discovery, Angiogenesis