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Tumor angiogenesis and its current treatment: a short review

Dhamraa Waleed Ahmed

 

EMAN Research and Testing Laboratory, Department of Pharmacology, School of Pharmaceutical Sciences, Universiti Sains Malaysia, Penang, Malaysia

*Corresponding Author. E-mail: dhamora@yahoo.com

 

Angiotherapy, 2017, 1(1), 044–047. (Received 11 September 2016, Published 10 May 2017). 

https://doi.org/10.25163/angiotherapy.11001121108100517

 

Citation: Dhamraa Waleed Ahmed. (2017). Tumor angiogenesis and its current treatments: a short review, 1(1), pages 04-047.

Abstract

Angiogenesis is the process of formation new blood vessel. This process involves the migration, differentiation and growth of endothelial cells that line the inside wall of blood vessels (Folkman, 2007). Angiogenesis and inflammation, two host-dependent and interdependent hallmarks of cancer, play a critical role in the growth and spread of cancer. Tumors can stimulate angiogenesis by giving off chemical signals to increase blood flow to the tumor by promoting nearby normal cells to produce angiogenesis signaling molecules (Sturk, 2005). During critical tumor growth, the diffusion of nutrients and oxygen to the center of the tumor can become difficult, which causes a state of cellular hypoxia that marks the onset of tumoral angiogenesis. New blood vessel development during tumor progression favors the transition from hyperplasia to neoplasia or the passage from a state of steady-state cellular division to a state of uncontrolled proliferation, characteristic of tumor cells. This state then influences the dissemination of cancer cells throughout the entire body (metastasis formation). On the other side, there is anti-angiogenesis mechanisms process interfere with blood vessel formation (Eichhorn, 2007).

 

Keywords: VEGF, vascular endothelial growth factor